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KMID : 1161519990030030259
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Animal Cells and Systems
1999 Volume.3 No. 3 p.259 ~ p.267
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Differential expression of NCAM-180 in the olfactory system and retina of the rat
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Koo Hye-Young
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Abstract
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The expression of the neural cell adhesion molecule?180 (NCAM?180), which accumulates at contact sites between cells and may be responsible for the stabilization of cell contacts, was studied in the olfactory system and retina of developing and adult rats. From embryonic day 12 onwards, which was the earliest stage examined, the NCAM?180 pathway directing to the presumptive olfactory bulb was observed. In later stages, olfactory neurons and fasciculating axons in the olfactory epithelium and nerve fiber layer and glomeruli of the olfactory bulb expressed NCAM?180. From postnatal day 0, immunolabelling pattern of the olfactory epithelium and olfactory bulb were the same as that during later stages. NCAM?180 immunoreactivity was present on differentiating retinal cells and persisted on those cells throughout adulthood. However, contrary to the olfactory nerve which remained detectable in the adult, the optic nerve was only transiently expressed with NCAM?180 and was no longer detectable in the adult. The presence of NCAM?180 in olfactory tissues suggests their possible role in pathfinding, differentiation, fasciculation and synaptic plasticity. The continued presence of NCAM?180 in the olfactory system examined may underlie its continuous cell turnover and regenerative capacity. The continuous expression of NCAM?180 in ganglion cells, bipolar cells and photoreceptor cells, also suggests potential regenerating capability and some plastic functions for these cells in the adult. Since the expression of NCAM?180 by the optic nerve was restricted to the period of special histogenetic events, for example, during axonal growth and synaptogenesis, it is possible that the lack of NCAM?180 in the adult optic nerve might cause a nonpermissive environment for the regeneration and result in regenerative failure of this system.
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KEYWORD
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NCAM-180, Olfactory epithelium, Olfactory bulb, Retina, Optic nerve, Regenerative capacity
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